In-Silico Test of Activity Apigenin as a Natural Compound in Reducing Uric Acid Level

EasyChair Preprint 7197

Abstract

This study aims to determine the bioactivity of these compounds apigenin on Apium graveolens as a medicine lowering uric acid levels. Chemical structure of compound apigenin contained in Apium graveolens taken from the literature. The target protein used is Interleukin 17-A. Water molecules were removed using PyMol v2.5.2 Software. Docking between the target protein and the compound was performed using PyRx-Python Prescription 0.8 Software. The results showed that the compound apigenin has a greater potential for lowering uric acid levels compared to control compounds. The affinity value of Interleukin 17-A with Apigenin is -6.4 while the affinity value of Interleukin 17-A with Allopurinol is -4.8. Compound toxicity test Apigenin The results showed that this compound was not a potential carcinogen.

Keyphrases: Allopurimol, Apigenin, Apium graveolens, Interleukin-17A

@booklet{EasyChair:7197,
  author    = {Andi Irwan Muluk and Andi Ariyandy and Ika Yustisia and Sulfahri Sulfahri},
  title     = {In-Silico Test of Activity Apigenin as a Natural Compound in Reducing Uric Acid Level},
  howpublished = {EasyChair Preprint 7197},
  year      = {EasyChair, 2021}}